Target the root cause of skin aging with the OS-01 peptide.

Target the root cause of skin aging with the OS-01 peptide.

All OneSkin Topical Supplements are formulated with OS-01, the first ingredient scientifically proven to reverse skin’s biological age at the molecular level. 01

All OneSkin Topical Supplements are formulated with OS-01, the first ingredient scientifically proven to reverse skin’s biological age at the molecular level. 01

7+


Years of Research

To develop the OS-01 peptide, our research-first approach leveraged evidence-based data to navigate the complexities of skin aging.

900+


Peptides Screened
We screened over 900 peptides to develop OS-01: The first peptide proven to reverse skin’s biological age01 by reducing senescent cell accumulation02.
17+

Patents and Publications

Our proprietary technology, including our rigorous in-house R&D process and the OS-01 peptide, is supported by three peer-reviewed scientific publications and 14 patents with many more pending.

4,300+


5-Star Reviews

Since launching in 2021, our proof goes beyond the lab with thousands of 5-star reviews and counting.

7+


Years of Research

To develop the OS-01 peptide, our research-first approach leveraged evidence-based data to navigate the complexities of skin aging.

900+


Peptides Screened
We screened over 900 peptides to develop OS-01: The first peptide proven to reverse skin’s biological age01 by reducing senescent cell accumulation02.
17+

Patents and Publications

Our proprietary technology, including our rigorous in-house R&D process and the OS-01 peptide, is supported by three peer-reviewed scientific publications and 14 patents with many more pending.

4,300+


5-Star Reviews

Since launching in 2021, our proof goes beyond the lab with thousands of 5-star reviews and counting.

Results That Go Beyond the Lab

BEFORE
AFTER

Kimberly W.

Our overall rating is 4.7 out of 5 stars from over 3,000 reviews
I have tried: medical grade topical treatments, several microneedling sessions (even with radio frequency), spa treatments, retinol /tretinoin, niacinamide, and a host of other topical beauty products. I’ve been seriously considering Botox and laser resurfacing, but really trying to avoid them…**Nothing** has made the visible difference that One Skin has! I’m on week 4 and I’m hooked! I might be able to avoid the more costly (money and time) procedures after all.
Female
45 - 54 years old
OS-01 FACE
BEFORE
AFTER

Barbara L.

Our overall rating is 4.7 out of 5 stars from over 1,200 reviews
I have only been using OS-01 BODY for about one month now and I am shocked at the results! The crepiness on my lower stomach and my upper arms has improved greatly. I am actually going to start wearing sleeveless dresses again!
Female
65 - 74 years old
OS-01 BODY
BEFORE
AFTER
Linda B.
Our overall rating is 4.8 out of 5 stars from over 190 reviews
I cannot believe how good and fast this works! I can see amazing results after only 8 days, using it twice a day. I had deep crow feet from hooded eyes and now the crow feet are starting to flatten out, almost disappearing. When I say it actually works, it’s not just maybe it looks a little better, I can definitely see a big difference.
Female
75 - 84 years old
01
/
03

Results That Go Beyond the Lab

BEFORE
AFTER

Kimberly W.

Our overall rating is 4.7 out of 5 stars from over 3,000 reviews
I have tried: medical grade topical treatments, several microneedling sessions (even with radio frequency), spa treatments, retinol /tretinoin, niacinamide, and a host of other topical beauty products. I’ve been seriously considering Botox and laser resurfacing, but really trying to avoid them…**Nothing** has made the visible difference that One Skin has! I’m on week 4 and I’m hooked! I might be able to avoid the more costly (money and time) procedures after all.
Female
45 - 54 years old
OS-01 FACE
BEFORE
AFTER

Barbara L.

Our overall rating is 4.7 out of 5 stars from over 1,200 reviews
I have only been using OS-01 BODY for about one month now and I am shocked at the results! The crepiness on my lower stomach and my upper arms has improved greatly. I am actually going to start wearing sleeveless dresses again!
Female
65 - 74 years old
OS-01 BODY
BEFORE
AFTER

Linda B.
Our overall rating is 4.8 out of 5 stars from over 190 reviews
I cannot believe how good and fast this works! I can see amazing results after only 8 days, using it twice a day. I had deep crow feet from hooded eyes and now the crow feet are starting to flatten out, almost disappearing. When I say it actually works, it’s not just maybe it looks a little better, I can definitely see a big difference.
Female
75 - 84 years old
01
/
03

Take it from the Experts

Dr Kara Fitzgerald
"First of all, I love OneSkin products. They work. But I also love OneSkin, the company. Why? They are a group of *badass* women scientists disrupting the archaic skin care industry with depth science demonstrating reversal of biological age of the skin. This is NOT the “it looks subjectively better” research (like Every. Other. Product.). OneSkin is demonstrating barrier repair, reduction in inflammation, reduction in the AGE of the skin, and oh yeah, did I mention they also happen to work?  We can see (and measure!) the results. Mic drop."
Kara Fitzgerald, ND IFMCP
Physician, Clinic Director
"Too many companies market their products as "anti-aging" without evidence. OneSkin is different. [...] I am continually impressed with the scientific rigor of the entire OneSkin team. I rarely recommend specific brand-name products to my patients, but OneSkin is unique—there is nothing similar on the market."
Adam Aronson, MD
Board-Certified Dermatologist, Fellow of the American Academy of Dermatology
“[OneSkin is a] groundbreaking company, because it's driving the science of skin rejuvenation in a new and hugely promising direction.” - Excerpt from Life Force by Tony Robbins
Tony Robbins
Author
Penn Smith, Esthetician
“I cannot remember ever evaluating a skincare brand that had more research and substantiation behind it. Ever.”
Penn Smith
Licensed Master Esthetician
"[OneSkin] developed a new molecular clock that’s quantifiable. That is real science.”
Dave Asprey
Founder of Bulletproof Nutrition

Take it from the Experts

Dr Kara Fitzgerald
"First of all, I love OneSkin products. They work. But I also love OneSkin, the company. Why? They are a group of *badass* women scientists disrupting the archaic skin care industry with depth science demonstrating reversal of biological age of the skin. This is NOT the “it looks subjectively better” research (like Every. Other. Product.). OneSkin is demonstrating barrier repair, reduction in inflammation, reduction in the AGE of the skin, and oh yeah, did I mention they also happen to work?  We can see (and measure!) the results. Mic drop."
Kara Fitzgerald, ND IFMCP
Physician, Clinic Director
  • Dr Kara Fitzgerald
  • Penn Smith, Esthetician
"Too many companies market their products as "anti-aging" without evidence. OneSkin is different. [...] I am continually impressed with the scientific rigor of the entire OneSkin team. I rarely recommend specific brand-name products to my patients, but OneSkin is unique—there is nothing similar on the market."
Adam Aronson, MD
Board-Certified Dermatologist, Fellow of the American Academy of Dermatology
  • Dr Kara Fitzgerald
  • Penn Smith, Esthetician
“[OneSkin is a] groundbreaking company, because it's driving the science of skin rejuvenation in a new and hugely promising direction.” - Excerpt from Life Force by Tony Robbins
Tony Robbins
Author
  • Dr Kara Fitzgerald
  • Penn Smith, Esthetician
Penn Smith, Esthetician
“I cannot remember ever evaluating a skincare brand that had more research and substantiation behind it. Ever.”
Penn Smith
Licensed Master Esthetician
  • Dr Kara Fitzgerald
  • Penn Smith, Esthetician
"[OneSkin] developed a new molecular clock that’s quantifiable. That is real science.”
Dave Asprey
Founder of Bulletproof Nutrition
  • Dr Kara Fitzgerald
  • Penn Smith, Esthetician
Meet the Founders
Founded by four female PhDs with expertise in stem cell biology, skin regeneration, bioinformatics and aging.
Meet the Founders
Founded by four female PhDs with expertise in stem cell biology, skin regeneration, bioinformatics and aging.
Propelled by a shared mission to change the way humans experience aging.
We donate 0.5% of sales to the Shepherd’s Centers of America (SCA), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning. 
We also donate 0.5% of sales to Lifespan.io, a non-profit crowdsourcing platform for the advancement of emerging medical technologies to address aging. Like us, Lifespan.io believes that everyone should be able to enjoy longer and healthier lives that are free from age-related diseases.
Propelled by a shared mission to change the way humans experience aging.
We donate 0.5% of sales to the Shepherd’s Centers of America (SCA), which provides enriching opportunities for lifelong learning, volunteer service, healthy living, and community connections - all of the things that give life meaning. 
We also donate 0.5% of sales to Lifespan.io, a non-profit crowdsourcing platform for the advancement of emerging medical technologies to address aging. Like us, Lifespan.io believes that everyone should be able to enjoy longer and healthier lives that are free from age-related diseases.
01 Measured in lab studies on human skin samples and using MolClock, a proprietary algorithm that predicts skin's biological age (
Zonari, A., et al. npj Aging, 2023) (Boroni, M. et al. Clinical Epigenetics, 2020)
02 Shown in lab studies on huamn skin samples and/or cells (
Zonari, A., et al. npj Aging, 2023)
01 Measured in lab studies on human skin samples and using MolClock, a proprietary algorithm that predicts skin's biological age (
Zonari, A., et al. npj Aging, 2023) (Boroni, M. et al. Clinical Epigenetics, 2020)
02 Shown in lab studies on huamn skin samples and/or cells (
Zonari, A., et al. npj Aging, 2023)