OS-01 Topical Supplement

The first topical supplement of its kind designed to extend your skinspan by improving skin health and skin strength. Our proprietary peptide, OS-01, has been shown to rejuvenate your skin on a molecular level and effectively treat the negative implications of aging.

  • Scientifically developed by a team of female PhDs
  • Safe beauty (meets the strictest criteria for transparency and health)
  • Vegan and cruelty free
  • Safe for all skin types (because we all age!)

How to use

  • Apply 1-2 pumps onto skin as a daily essential moisturizer.
  • Where: Face, neck and hands.
  • When: Morning and evening after cleansing.


Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide.


What is a Topical Supplement?
Just like you take vitamins and oral supplements every day for your general health and immunity, our Topical Supplement is a peptide moisturizer designed to improve your skin’s health and its subsequent appearance.
Topical Supplements are applied to specific areas of the skin to deliver targeted and visible skin repair results. Our Topical Supplements deliver OS-01, a proprietary peptide that extends your skin health, or your skinspan.
What is skinspan?
Skinspan refers to the length of time that your skin is healthy. For many, healthy skin presents as supple, smooth, and strong. Our mission is to extend your skinspan by optimizing skin health on a molecular level, increasing skin resilience and strength.
Unlike other skincare products that offer short-term solutions (and might even cause long-term damage), our Topical Supplements target the root causes of aging skin, including cellular damage and the accumulation of aged skin cells, for long-term, visible results.
How is OS-01 FACE formulated for use on areas exposed to the most damage (face, hands, and neck)?
The skin on the face, neck, décolletage, and hands is thinner and more delicate than the rest of the skin on the body. These areas of thin, delicate skin are the most likely to wrinkle, sag, lose elasticity, and show visible signs of premature aging.
Additionally, the delicate skin on the face, neck, décolletage, and hands are most exposed to (environmental) stressors like the sun, UV rays, dry air, cold and windy weather, air pollution, and other external sources that damage skin health and vitality, which are key contributors to skin’s appearance.
In order to combat environmental damages and premature aging of the facial skin, OS-01 FACE delivers an optimized concentration of the OS-01 peptide to reduce the skin’s biological age, support powerful cellular repair, and boost barrier function.

OS-01 FACE specifically benefits the more delicate skin of the face, neck, and hands by:

  • Sorting cellular repair and barrier function
  • Increasing epidermal thickness
  • Supporting collagen and elastin production, for stronger, firmer skin0
  • Supporting hyaluronic acid production, to boost hydration
  • Minimizing redness
  • Increasing skin silkiness and smoothness
We recommend applying OS-01 FACE to the most delicate and/or damaged/exposed areas of your skin, like the face, hands, and neck.
For all other areas, we recommend using OS-01 BODY.
Why is OS-01 FACE delivered topically?
Topical delivery ensures maximal penetration by the OS-01 peptide and efficacy to a specific area of skin. Through targeted topical application, the OS-01 FACE Topical Supplement is best able to deliver visible, noticeable improvements to the skin.
It’s also important to note that the science on the efficacy of ingestible skincare supplements is still out. Ingestible skincare supplements often degrade in stomach acid and fail to deliver any quantifiable, noticeable benefits to the skin. Combined with a healthy and balanced diet, Topical Supplements are your most effective tool to achieve faster, more visible improvements to the skin.
Is OS-01 FACE safe?
We’ve applied vigorous scientific rigor and exacting standards into formulating the safest, most effective Topical Supplements possible.
The Environmental Working Group (EWG) rates each skincare ingredient on a scale of 1-10, with a score of 1 being the safest and healthiest. OS-01 FACE received an average score of 1.02 and a weighted average of 1.04 on the EWG’s SkinDeep Cosmetics Database.
OS-O1 FACE was tested for human sensitization (RIPT - a clinical study to assess skin irritation) and various other toxicity tests. No adverse effects were found.
OS-01 FACE is clean, vegan, and cruelty free.
How should I integrate the OS-01 FACE into my current skincare routine?
At its core, our Topical Supplement is a peptide moisturizer, so we recommend applying it after cleansing and before sunscreen.
OS-01 FACE has not been shown to produce adverse reactions with other products and can be safely incorporated into your current routine.
Remember, it’s always best to patch test any new skincare product.
How does OS-01 FACE compare to retinol?
OS-01 FACE is safer and more effective than retinol.
Retinol targets the symptoms of aging by stimulating cell renewal which leads to peeling off the upper epidermal layers. However, retinol is often too harsh for many skin types, especially sensitive and drier skin. Negative side effects of retinol can include redness, irritation, dryness, flaking, and damage to the skin barrier which can increase skin sensitivity. When misused or overused, retinol can even compromise skin health in the long term. Skin thinning and a less resilient, weaker skin barrier are potential outcomes of such misuse.
OS-O1 FACE is a safer, highly efficacious topical skincare supplement that targets the root cause of skin aging at the molecular level by preventing the accumulation of damaged cells and increasing cellular repair capabilities. OS-01 FACE is more gentle than retinol - and our data supports similar or better effects in improving collagen and hyaluronic acid production.
Do you ship internationally?
Currently, we only ship to the U.S. and Canada.
We are working on adding international shipping options. Sign up for our newsletter for updates as we continue to expand.
What is the approximate shelf life of OS-01 FACE? How should it be stored?
OS-01 FACE has a shelf life of 24 months. Refer to the QR code on the back of your bottle for more details.
Is OS-01 FACE safe for pregnancy / breastfeeding?
We have rigorously tested our Topical Supplement for its safety on various skin types, however, we have not tested OS-01 FACE with pregnant or breastfeeding mothers.
We recommend pregnant and breastfeeding mothers show the ingredients list to a doctor or healthcare provider to confirm safety before use. As always, it’s best to consult with a medical professional before making lifestyle changes.
Is your packaging recyclable?
We are working diligently towards making our packaging 100% recyclable.
We offer free shipping labels so you can easily return empty packaging to us. To request a free shipping label please email us at support@oneskin.co.
Is OS-01 FACE sustainable / environmentally friendly / carbon neutral?
We are committed to environmental sustainability and protecting the plant. We constantly aim to reduce our environmental impact while creating cutting-edge, scientifically formulated Topical Supplements that improve the health, appearance, and vitality of the skin.
We partner with Zero Carbon to offset our carbon footprint to zero.
Stay in the loop about our sustainability goals, product news, and more by signing up for our newsletter here.
How long will my OS-01 Topical Supplement last?
The 50 mL bottle of OS-01 FACE will last approximately 2-3 months, when used as directed.
Have any more questions?
For our comprehensive FAQ list click here.

Refillable Packaging

Not only does OS-01 FACE deliver cutting-edge science to skin care, it also leverages state of the art refillable packaging so our skin, bodies, and planet can remain healthy for the long-term.

The 100% recyclable plastic shell and plastic pump can be kept and reused. The pouch, containing the product, is now the only disposable packaging component of OS-01 FACE.


If you are a subscriber, you will receive the complete set of packaging components for your first shipment, then you will receive a replacement pouch in every shipment thereafter.

If you place a one-time purchase, you can choose whether you would like to receive the complete set of packaging components (plastic shell, plastic pump, and pouch containing product) or, if you already have the reusable packaging components, you can choose to purchase just a replacement pouch for a lower cost.

OS-01 RefillableOS-01 Refillable

Healthy Skin
Starts Within

There’s more to aging than just the wrinkles you see.

OS-01 FACE addresses the root causes of aging so skin doesn’t just look younger, it actually functions like younger skin.


775 Reviews

The first skin longevity treatment that extends skin health on the molecular level to address aging from within.


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You selected one-time purchase. Why not switch to our flexible subscribe & save program to save 17.5%?
30 day money back guarantee We are confident you will be more than satisfied with our product so much so that we offer a 30-day money back guarantee on your first order. What this means is, you can request a refund at any point within 30 days of your first purchase of the product and get your money back with no questions asked. That's how much we believe in our product! We do want to note, based on feedback, most customers state results around the 6 week mark of continued use. [ + ] read more Try it risk-free!
We are currently low in stock. As such, we are temporarily only offering 60 day subsciptions. 30 day and 90 day subscriptions will be be available once stock is replenished. Once you receive your 50 mL bottle, you will be able to modify your subscription to 30 or 90 days.

775 Reviews

would recommend this product to a friend
Fewer wrinkles and more protection against external stressors
Improves overall cell function
Helps maintain youthful and healthy skin
Increases skin firmness and strength
Makes your skin feel and look great
Reduces water loss and supports production of hyaluronic acid

Elevate your skincare routine

Firmer, Smoother, and Stronger Skin.

Scientifically and Clinically backed

OS-01 Supporting Data

As we age, our skin becomes less efficient at clearing away damaged skin cells that weaken healthy cells around them. The accumulation of damaged cells reduces skin resilience and triggers wrinkles, dark spots, and loss of firmness. OS-01 reduces the accumulation of damaged cells so that skin stays healthier for longer. In a 12-week clinical study, OS-01 was shown to:

12 Weeks
Base Line
  • Improve Skin Barrier (Average Improvement + 15%)*
  • Improve Skin Elasticity (Shown in 90% of users)**
  • Improve Skin Evenness,
    Radiance, Pores, & Firmness (Shown in 95.5% of users)**
  • Reduce Appearance of Fine Lines & Wrinkles (Shown in 87% of users)
  • Improve Skin Smoothness
    & Overall Appearance (Shown in 100% of users)

*Instrumental Evaluation - Vapometer analysis

*Double-blind expert clinical grader evaluation

Active Ingredients

Seven key ingredients that work with OS-01 to boost moisture, reinforce barrier function, and diminish skin stress


average rating 4.7 out of 5
Based on 19 reviews
  • 5 Stars
    15 Reviews
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95% of reviewers would recommend this product to a friend
Customer photos and videos
Review posted
Reviewed by Tracie N.
Verified Buyer
Rated 5 out of 5


Goes on smoothly and absorbs quickly. It's definitely improved the lines on my forehead and around my eyes....my skin feels like it has a general "tightness" that it didn't have before.

I recommend this product
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Review posted
Reviewed by Susan M.
Verified Buyer
Rated 5 out of 5

One and done

I see lightening smoothing of my skin. To have this improvement using just one product is phenomenal. I want my skin to look better over time with no fuss.

I recommend this product
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Review posted
Reviewed by Cindy C.
Verified Buyer
Rated 5 out of 5

Great Skin Caare

This is really a good skin product. It makes your skin supple without adding any greasy feel.

I recommend this product
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Review posted
Reviewed by Jaime L M.
Verified Buyer
Rated 5 out of 5

Great product!

Makes my skin feel stronger and less saggy. Dark spots have diminished and it feels brighter and makes me feel younger. Thank you

I recommend this product
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Review posted
Reviewed by Franciellen R.
Verified Buyer
Rated 5 out of 5


My journey with the OS-01 started before the product was released. I found about the product on the internet and I participated in the lives, read about the product proposal and about the journey of how it was developed. The product proposal fascinated me so I bought it . I'm on my 4th bottle. I LOVE the product. It leaves my skin so smooth and has really reduced my fine lines. I get a lot of compliments about my skin . The last one said I looked like I'm in my 20s (I'm 36yo). I will use the product for the rest of my life. Thank you

I recommend this product
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