OS-01 EYE Topical Supplement
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- Targets Dehydration, loss of elasticity, wrinkles
- Suited to All skin types, safe for sensitive skin
- Format Rich eye cream
OS-01 EYE is a targeted skin longevity treatment with the highest concentration of the OS-01 Senescence Blocking Peptide™, scientifically proven to support the ultra-delicate skin around the eyes.01,02
BENEFITS
Our most potent formula, specially designed for the delicate skin around the eyes, which is prone to accelerated aging 03
Wrinkle reduction
Boosts collagen to visibly smooth lines and wrinkles.01
Firmness
Supports skin health for a firmer, more lifted appearance.01
Hydration
Strengthens the skin barrier to lock in moisture and keep skin hydrated.01
5-star reviews
See why customers love OS-01 EYE
“The concentration of peptides in this product has made a difference, especially to the circles under my eyes. I haven’t needed to use concealer since beginning to use this product. The science behind this product is solid.” – Kathy L.
"I've tried all sorts of different eye creams; the best out there. I have a very thin skin around my eyes with many expression lines and wrinkles and this product has been the most efficient in minimizing them and nourishing my skin. I all using this day and night very religiously and have no intention of ever stopping." – Archontia T.
"I simply love One Skin OS-01 Eye cream. It is silky smooth, absorbs efficiently, and never feels heavy or greasy. I have noticed the fine lines under my eyes and early crows feet slowly vanishing. It's subtle but evident the more I use it. This is the best product I have ever tried." – Bridgette G.
"OS-01 EYE is fantastic. I wish I had taken pictures when I started using this a year ago. I'm certain my eyes look better now than they did before. It absorbs immediately and yet is there moisturizing the area around my eyes all day long. It even smooths out the rough bumps around my eyes. This is a wonderful product. I love it!" – Donna G.
The proof is in the pictures
CLINICAL DATA
Visible results, scientifically validated
95.5
of participants reported improved texture and tone 01
90.9
of participants reported improved radiance 01
87.5
of participants showed improved hydration 01
86
of participants had improved elasticity 01
The Science Behind OS-01 EYE
The skin around the eyes is among the thinnest on the body, making it exceptionally delicate and prone to aging.04 This vulnerability leads to higher levels of cellular senescence,03 leaving the eye area more susceptible to sagging and wrinkles.
OS-01 EYE was specifically designed to address the unique needs of this fragile skin, delivering the highest concentration of our OS-01 peptide for unparalleled skin health benefits.
In lab studies, our scientists analyzed key aging biomarkers in human skin samples before and after treatment. Their findings show that OS-01 EYE:
- Promotes collagen retention (decrease in MMP1)02
- Reduces a key biomarker associated with cellular senescence (CDKN2A)02
- Lowers a key biomarker linked to inflammation (IL-8)02
Shown in lab studies on ex vivo human eyelid skin samples by analyzing levels of collagen in skin treated with OS-01 EYE compared to no treatment. Skin treated with OS-01 EYE displayed a significant increase compared to skin with no treatment.
3 active ingredients complement the OS-01 peptide
Getting started with OS-01 EYE
Follow these easy steps for optimal results
- Dispense 1 pump onto tip of finger
- Gently tap in a semi-circle around each eye, from the under eye to the eyelid and underneath the brow bone
- Use 2 times daily
How it works
Powered by the OS-01 Senescence Blocking Peptide™
The first and only peptide scientifically proven to reverse skin’s biological age.05,06
All Ingredients
Water, Glycerin, Sorbitan Olivate, Squalane, Cetearyl Olivate, Butyrospermum Parkii (Shea) Butter, Simmondsia Chinensis (Jojoba) Seed Oil, Cystoseira Humilis Extract, d-Panthenol, Bentonite, Cetyl Palmitate, Sodium Hyaluronate Crosspolymer, Caprylhydroxamic Acid, Sorbitan Palmitate, Cellulose, Coffea Arabica (Coffee) Seedcake Extract, Allantoin, Fucus Vesiculosus Extract, Gluconolactone, Niacinamide, sh-Polypeptide-121, Sisymbrium Irio Seed Oil, Tocopheryl Acetate, Sorbic Acid, Caprylic/Capric Triglyceride, Ubiquinone, Lecithin, Decapeptide-52*, Sodium Chloride, Maltodextrin, Acetyl Hexapeptide-8, Moringa Oleifera Seed Extract, Glyceryl Caprylate, Caprylyl Glycol, Tetrasodium Glutamate Diacetate, Alcohol, Sodium Benzoate, Phenoxyethanol, Xanthan Gum. *OS-01 Peptide.
Citations
01 Zonari, A., et al. Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging. Int J Cosmet Sci. 2025; 00: 1–11. doi:10.1111/ics.13042
02 Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims
03 New biological insights into skin aging around the eye. Journal of the American Academy of Dermatology, Volume 74, Issue 5, AB28 https://doi.org/10.1016/j.jaad.2016.02.112
04 Tagami, H. (2008), Location-related differences in structure and function of the stratum corneum with special emphasis on those of the facial skin. International Journal of Cosmetic Science, 30: 413-434. https://doi.org/10.1111/j.1468-2494.2008.00459.x
05 Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1
06 Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1
OS-01 EYE Topical Supplement
- MOMariya O.Verified BuyerReviewingOS-01 EYE Topical SupplementI recommend this productRated 5 out of 5 starsYesterdayExcellent Eye Cream
Feels great. I'm using twice a day. I also use as a serum on some of my face and neck line. Lasts well, easily absorbed. I'm hooked.
OneSkinYesterdayHi Mariya!
Thank you for the review! A support team member will be reaching out shortly!
- CAChase A.Verified BuyerReviewingOS-01 EYE Topical Supplement RefillI recommend this productRated 5 out of 5 stars2 days agoOneSkin Eye Cream Review – Remarkable Progress, Real Science
I'm 60 years old, and after several weeks of using OneSkin’s eye topical, I’m genuinely stunned by the results so far.
As someone in a visually creative field, I need to push back against ageism in every way I can. From the shoulders down, thanks to decades in the gym, I look 35. But the eye area told a different story—puffy, saggy, and older than I felt inside. That’s changed. While I haven’t reached my final goal yet, the transformation already underway is unlike anything I’ve experienced from a topical.
I’m further along than I ever imagined possible at this stage, and I know the progress will continue. Each week, I see the signs of aging around my eyes reversing—skin tightening, puffiness fading, and a more youthful look emerging. I’ve never had that experience with any other product.
As someone deeply rooted in wellness—nutrition, fitness, and the science of longevity—I consider this a major advancement in the anti-aging toolkit. Aging is a privilege, but aging well is a choice. And OneSkin is helping me make that choice visible.
To the creators of this product: thank you. You’ve given me the first skincare product that truly aligns my appearance with how I feel on the inside—and that’s priceless.
- BLBethany L.Verified BuyerReviewingOS-01 EYE Topical SupplementI recommend this productRated 5 out of 5 stars2 days agoHoly grail of eye creams
This cream is deeply moisturizing and absorbs quickly. love it!
- NFNorma F.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars3 days agoRefill
The product helps reduce the wrinkles under my eyes. It absorbs well and not greasy.
- CSCandice S.Verified BuyerReviewingOS-01 EYE RefillI recommend this productRated 5 out of 5 stars3 days agoLove this eye cream!
I’ve been using OS-01 twice daily for a few months and love how it moisturizes and wears under my makeup during the day as well as at night. Would definitely recommend!
