Product Overview

What size is the bottle?


What is OS-01 and what does it do?

OS-01 is a topical supplement you apply to your face, neck, and hands after cleansing. It is a proprietary peptide designed to extend your skinspan on a molecular level by improving internal markers of skin health and external markers of skin strength.

OS-01 reduces your skin's biological age and improves the skin barrier. OS-01 also increases skin strength on the surface level by optimizing the molecular health of your skin, OS-01 improves the external strength of your skin. Feel and look your best with firmer, smoother, and more hydrated skin.

What is a topical supplement?

Just like taking vitamins everyday for general health and immunity, our topical supplement delivers OS-01, a proprietary peptide that extends your skin health (aka your skinspan). Unlike other skincare products that offer short-term solutions (and might even cause long-term damage), we target the root causes of aging on the molecular level for long-term results, and by applying it topically we ensure that the benefits are going where they should be.

How long will my OS-01 supplement last?

We estimate the 50 ml bottle of our Topical Supplement will last approximately 1-3 months when used as directed.

Is your topical supplement safe?

Yes, OS-01 is completely safe. We’ve applied the same scientific rigor into formulating a safe product as we did for effectiveness. EWG rates ingredients on a scale of 1-10, with a score of 1 being the safest and healthiest. OS-01 received an average score of 1.08 and a weighted average of 1.02. Our supplement was tested for human sensitization (RIPT - a clinical study to assess skin irritation) and various other toxicity tests, and no adverse effects were determined.

How does your topical supplement compare to retinol?

Retinol works to target the symptoms of aging (ie. fine lines and wrinkles) by stripping the skin of its cells on its outermost layer in order to make room for younger, healthier cells. In this process, while retinol is stripping away older cells, it also removes already young, healthy cells with. When mis or overused, this can cause long-term damage due to the exhaustion of your stem-cells pool, and raise skin inflammation levels. OS-01 is fundamentally different and was specifically designed to treat the root cause of skin aging, while retinol targets the symptoms. Instead of stripping your skin of all cells, OS-01 selectively targets the older and dysfunctional cells in the skin, without disturbing your young, healthy cells to keep your skin healthy. With this approach, OS-01 is more effective in improving your skin health long-term with no side-effects. If you would like to combine your retinol products with OS-01, we suggest using retinol 2-3 times a week (at most) and applying OS-1 immediately after to counteract any potential damage or side effect caused by retinoids.

What is the shelf life of your topical supplement? How should it be stored?

Our topical supplement has a shelf life of 16 months. OS-01 should be stored at room temperature and out of direct sunlight.

What is OneSkin doing for sustainable packaging?

Our box is 100% recyclable.

We are working to develop a bottle that will be made from partially recycled material. Currently, once you have finished using our product, you can email support@oneskin.co to request a free shipping label to return the empty bottle to us. The empty bottle can be returned in the original box or any other packaging of your choice.

Additionally, we are developing a refillable option for OS-01 FACE Topical Supplement subscribers and all future product packaging will be chosen with sustainability in mind.

Lastly, we have partnered with Zero Carbon to offset our carbon footprint to zero! Stay tuned for more updates on our sustainability goals!


Product Usage

How should I integrate OS-01 into my current skincare routine?

At its core, our topical skin supplement is a moisturizer, so we recommend applying the product directly after cleansing and before applying a sunscreen. Although we're confident your skin will look its best from just using OS-01 and sunscreen daily, the good news is that our product has not been shown to have adverse reactions with other products and ingredients, including retinol, vitamin C, and hyaluronic acid. This means that you can safely incorporate OS-01 into your current routine without any additional changes.

Is OS-01 safe to use while pregnant/breastfeeding?

Our topical supplement is as safe and effective as can be. We have rigorously tested it’s safety on various skin types, however, we have not tested it on pregnant or breastfeeding individuals. Because of this, we recommend those who are pregnant or breastfeeding show our ingredients list to your doctor or health care provider to confirm before using.

Can my child use OS-01?

While OS-01 is safe to use, we recommend it for all adults over the age of 18.

Science Behind Product

What is skinspan?

Skinspan refers to the length of time that your skin is healthy. Our mission is to extend your skinspan by optimizing skin health on a molecular level and increasing skin strength!

How is your product different from a regular moisturizer?

Our topical supplement contains a proprietary peptide, OS-01, that not only will nourish your skin, but it will also proactively extend your skin health on a molecular and external level.

Why is OS-01 delivered topically?

Topical delivery allows for our peptide to be applied to a specific area of skin to maximize penetration and efficacy. In the lab, we measure how OS-01 affects both the dermis and epidermis specifically. More importantly, ingestible supplements often degrade in stomach acid and therefore have no direct effect on the skin, but when applied topically there can be real (and measurable) effects.

What current research are you working on?

Due to competitive reasons, we cannot share the research we are currently working on. When we finish our research, we will announce any findings and concluded studies in our marketing emails/newsletters.

Is there any human data available on OS-01? Has it been published?

While we haven’t published any of our clinical data in a scientific journal yet, we have completed a clinical study with 22 patients where we found significantly positive data that OS-01 can improve the skin barrier, texture, hydration, and reduce fine lines and wrinkles. We also have an ongoing clinical study where we are looking at OS-01’s ability to reduce the skin’s biological age over 6 months time. We can’t wait to share the results!

I’ve read everything on your website, where can I go for more information?

You can read further into our molclock abstract here and you can also sign up for our newsletter to receive our new science blog posts. You can also read more from our reference lab here.


What are the ingredients in OS-01?

Water (aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide

Is OS-01 fragrance free?

Yes, OS-01 is fragrance free. Due to natural ingredients, you may pick up on their own fragrances, but there is no added fragrance to our product.

Where is OS-01 Manufactured?

OS-01 topical supplement is manufactured in California

Where do you source your ingredients for OS-01 from?

We only use the highest quality ingredients available, which are sourced globally.



Do you offer international shipping?

We are able to ship to all addresses in Canada. We are not yet able to ship to any other countries outside the US and Canada.
With shipments outside of the United States, we ship DDP (Delivered Duties Paid).

Shipping duties and taxes are all included in the final price.
If you have any additional questions please reach out to our support team at support@oneskin.co

How long does shipping take?

We estimate shipping will take about 5-7 days to arrive to you. Sometimes packages may arrive sooner than anticipated. Couriers depend on the location and expected timing of the shipment. Please refer to your tracking number to determine which courier will be used.

Do you offer expedited shipping?

Yes, we offer expedited shipping, but all orders placed after 12noon PST will not process until the following business day. Orders placed on Thursday after 12noon PST or Friday will not process until the following Monday..

How long do I have to update my shipping information after an order is placed?

Once an order is placed, it will be processed within 30 minutes, making changes to the shipping address no longer possible. Due to this we cannot update a shipping address after it has been placed, please double-check all shipping information before placing an order.

My package says it has been delivered, but I don’t have it.

We encourage you to reach out to your courier and create a ticket with them using your tracking number. After you do this, please reach out to our support team at support@oneskin.co for further assistance.

What happens if my package is returned to sender due to a delivery error (wrong address, delivery complications, no access to location, etc.)

For any “Return to Sender” packages or delivery issues with USPS, we will issue you a refund when your package is received in our warehouse. Sadly, we’re unable to reship packages once they leave our facility. Your tracking information will show you detailed info marked by your courier, and you may reach out to them for further information and try to intercept and schedule a pick up at your local office.

Where can I view my tracking information?

After you place an order, you will get an email from us confirming your order and the tracking information will be included in that email. You will also be able to view your tracking information right through your account on our website.

My items broke during delivery, can I get a new one?

We apologize for any issues that arose during the shipping process. Please reach out to our support team at support@oneskin.co with your product and pictures showing the damage that occurred through shipping. They will be able to help assess and either refund or send a new shipment out to you.

My order status says unfulfilled, what does that mean?

An unfulfilled status means your order has not yet been processed and packaged. You’ll be notified via email with tracking information as soon as a label is created in our system.

Refunds, Returns, Cancellations

What is your refund policy?

We are confident you will be more than satisfied with our product so much so that we offer a 30-day money back guarantee on your first order. What this means is, you can request a refund at any point within 30 days of your first purchase of the product and get your money back with no questions asked. That's how much we believe in our product! We do want to note, based on feedback, most customers state results around the 6 week mark of continued use.

Do you offer price adjustments?

While we do not offer price adjustment, we will periodically offer special promotions/discounts throughout the year. These will be announced via email when they are active.

How do I cancel an order?

Before you place your order, you can view the contents and the total amount in your shopping cart. Once your order has been placed, it is immediately sent to our fulfillment center to begin processing for order delivery. Due to this, we are unable to make any cancellations or changes to submitted orders, regardless of its current status.

I forgot to cancel my subscription, can I return the current shipment for a refund?

Yes, please contact us at support@oneskin.co and we will set up a return label for you that you can print out to send your shipment back, upon receiving your order we will issue your refund.


Can I make changes to my order once it's placed?

Once an order is placed, a label is created shortly after. We do not have the ability to adjust or make changes to your order at this time.In the case an incorrect address is entered during the checkout process, we cannot guarantee that changes can be made. However, in the event that the package is sent back to us, we can offer a refund on the items.

Do you offer OS-01 for wholesale distribution?

We are not currently offering OS-01 for wholesale distribution. If you have any further questions about wholesale distribution you can reach out to our support team at support@oneskin.co.

Do you have an affiliate program?

We have an Ambassador Program and a Professional Partner Program. If you would like to join either program, please reach out to our support team support@oneskin.co.

Do you have a referral program?

Yes, we do! You can give $20 to a friend/family member that is good for a single bottle purchase only, and when they use your code, you will automatically receive $20 off your next purchase.

How can I apply a discount code to an existing subscription plan?

1.) Visit to oneskin.co

2.) Click "Account" in the top right corner

3.) Click "Manage your subscriptions"

4.) Click "Edit"

5.) Scroll down and click "Apply Discount"



Account Information

How to create an account?

(Important Note: You need to create an account to manage your subscription.)

You can update your payment information right through your account on our website. You can also reach out to our support team at (855) 444-6840 and update it over the phone.

  1. Click "Account" on top right of oneskin.co homepage

  2. Click "Sign Up Here" in top right

  3. Create account using the same email associated with your subscription

How do I update my payment information?

You can update your payment information right through your account on our website. You can also reach out to our support team at (855) 444-6840 and update it over the phone.

How do I reset my password?

You can reset your password through your account settings. If you cannot get into your account to reset your password, you can enter your password on our login page and select ‘Forgot Password’ which will send you an email to update your password.

How do I update my email address?

You can update your email address right through your account on our website. You can also reach out to our support team at support@oneskin.co or by phone at (415) 851-6677.

Contact us

What is your customer support phone number?

 1 (415) 851-6677 

What is your customer support email address?

You can reach out to our support team at support@oneskin.co.

I’m an agency, brand, influencer, etc. who can I reach out to for a collaboration?

Please reach out to our PR team at support@oneskin.co.

How do I unsubscribe from your emails?

We are sad to see you go! To unsubscribe or manage your email preferences, open one of our emails, scroll down to the bottom of the email, and click “Unsubscribe”.

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