Anti-Aging Reinvented

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The first Topical Supplement designed to extend skin health on the molecular level by targeting aging from within.

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We have a secret… We aren’t a skincare company

We are a longevity company. Our team is comprised of PhD-level aging experts. We’ve spent years in a lab creating the first topical skin supplement designed to extend your skinspan; the time your skin is healthy and youthful. And here you thought all supplements were pills.

Right for all skin types
(we all age, after all)
Data-backed claims
peptide, OS-01
Developed by longevity Scientists
Vegan and cruelty free
Safe and clean ingredients

Healthy skin looks great on everyone

(Just take it from our customers!)


“Other products can moisturize, some can make your skin look younger (at the cost of thinning skin). But this one makes the skin healthier! In my case, my (not very severe) rosacea disappeared, my skin looks younger and firmer, and wrinkles much less apparent. I've always neglected my skin and, at 73, it showed. But now my skin looks and feels great! Can't wait for the body lotion to come on the market!”

-Richard S.

“I am loving this. I've tried pretty much everything out there. This actually works. I am 75 . Firmness of skin is improved, fine lines and wrinkles diminished! Neck is much improved. My esthetician was very impressed.”

-Cindy Y.

“At 67, having ceased taking hormone replacement therapy (HRT) about three years ago, I have been dismayed at how dry and wrinkled my skin has become. Using One Skin daily for almost two months, I see a distinct improvement in the suppleness and youthfulness of my face.”

-Emily W.

“I have practiced functional medicine for more than 30 years. The changes to some areas of my skin have been very interesting. No cream I have used in the past has been able to produce these changes. I don't have unhealthy skin , but the OS-01 has made some areas of my skin look like it did 40 years ago. I can absolutely recommend this product.”

-Didrik S.

“Both me and my wife saw immediate improvements in skin texture, skin tone, skin hydration levels. Wrinkles visibly reduced. Overall skin appears younger, more elastic, and healthier.”

-Adrian M.

“This is the best skin cream I have ever used. Better than GHK-Cu. Better than everything!! My skin looks so smooth and young and healthy. I’m so impressed.”

-Amy W.

“This is the best face cream I’ve ever used. I’ve spent 40 years playing tennis in the California sun and it beat up my skin pretty badly. One skin fixed it in a month and now it gets better every week.”

-Keith W.

“This is by far the most effective product I’ve used to date. I have tried all sorts of anti-aging moisturizers and this has them all best hands down. Luxurious feel and scent!”

-Megan L.

“My friend gave it to me as a gift. At first I thought, "Ugh, another useless skincare," but then she told me about all the great scientific proofs and results, so I gave it a try. It really made my skin look better, softer, and small wrinkles disappeared. I can't wait to make another order!"

-Arzu A.

"In a space that is so saturated with overhyped products, it's refreshing to see a brand that stands for evidence, efficacy, and holistic health. My skin feels brighter, softer, and overall smoother, it's my new go-to!"

-Dara E.

“I have always been obsessed with products that have both a health benefit and positive physical impact. And while there are tons of products that claim to do this on the market today, none that I’ve tried have even come close to the visibly measurable improvement in my skin I’ve seen in just 8 weeks! OneSkin is the one product I don’t see ever leaving my skin care routine!”

-Brandon S.

Scientifically and Clinically backed

OS-01 Supporting Data

We performed a 12-week clinical study to validate and quantify the impact of OS-01 in improving skin health. Our results showed that OS-01 is clinically proven to strengthen the skin barrier, reduce wrinkles, and provide remarkable visual benefits against common signs of aging, making it the perfect product for mature skin.

12 Weeks
Base Line
  • Improved Skin Barrier (Average Improvement + 15%)*
  • Improved Skin Elasticity (Shown in 90% of users)**
  • Improved Skin Evenness,
    Radiance, Pores, & Firmness (Shown in 95.5% of users)**
  • Less Wrinkles (Shown in 87% of users)
  • Improved Skin Smoothness
    & Overall Appearance (Shown in 100% of users)

*Instrumental Evaluation - Vapometer analysis

*Double-blind expert clinical grader evaluation

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Meet OS-O1, the first ingredient to target the root causes of skin aging

Our product acts at the molecular level. Our proprietary peptide, OS-O1, is scientifically proven to

Plus, it will leave you with younger looking and feeling skin, making it the perfect product for mature skin.

Healthy skin is happy skin

(Just take it from our beta testers)


As a brand whose mission is to inspire healthy aging, we don’t identify with the term “anti-aging” and here’s why:

Much of the anti-aging skincare industry has been built on empty promises with top anti-aging products lacking validated claims and exploiting age-related anxiety and fear.

At OneSkin, we recognize that the goal of the best anti-aging skincare products shouldn't be only to improve appearances, which often forces consumers to compromise on long-term skin health, but rather to treat the underlying source of skin aging, a consequence of which will be improved appearances.

We are developing best-in-class solutions to aging with a new mindset - one that’s not anti-aging, but pro-aging in the healthiest and most beautiful way possible. We believe the best anti-aging treatment is one that is rooted in science, with data-backed claims. That’s why our Topical Supplement goes beyond placing a metaphorical band-aid on aging skin — it addresses the molecular changes associated with aging to not only boost skin health, but overall health as well.

Skin health is a marathon, not a sprint

In the same way you take daily vitamins to keep yourself healthy, daily application of our science-backed topical supplement promotes long-lasting effects to keep your skin healthy, hydrated, and strong.

Unlike other top-rated anti-aging treatments, which promise quick fixes or only offer temporary relief, OneSkin promotes long-term skin health at the molecular level. Our topical supplement works over time, penetrating the deepest layer of the skin to stimulate lasting change and restore skin’s resilience, making OneSkin the best product for mature skin. Most users start seeing healthier, stronger, and better looking skin in 4-8 weeks with daily use.

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