Product Overview

What is OS-01 and what does it do?

OS-01 is OneSkin’s proprietary peptide, which sits at the heart of OneSkin’s product formulations and powers OneSkin’s Topical Supplements.

The OS-01 peptide was discovered from years of research by the OneSkin team and works by improving internal markers of skin health and external markers of skin strength, effectively extending your skinspan (the length of time that your skin is healthy and strong).

Using our cutting-edge R&D process & molecular clock, the scientists at OneSkin have shown that the OS-01 peptide reduces skin's biological age and improves skin function.

Additionally, the OS-01 peptide has been shown to:

  • Increase epidermal thickness and improve cellular structure, for optimal barrier function
  • Support collagen and elastin production, for stronger, firmer skin
  • Support hyaluronic acid production, to boost hydration 
  • Repair UV damage and reduce the amount of aged cells in skin, so skin stays healthier for longer
  • Reduce hyperpigmentation in skin, otherwise known as “sun spots” and “age spots”

What is a Topical Supplement?

Just like you take vitamins and oral supplements everyday for your general health and immunity, a topical supplement is a formulation designed to improve the health and appearance of the skin.

Topical supplements are applied to specific areas of the skin to deliver targeted, visible results. Our topical supplements deliver OS-01, a proprietary peptide that extends your skin health, or your skinspan.

What is the difference between OS-01 FACE and OS-01 BODY?

OS-01 BODY is specially formulated for use on your body’s skin and OS-01 FACE is specifically formulated for use on your face. Read the next two questions for more details..

How is OS-01 FACE formulated for use on areas exposed to the most damage (face, hands, and neck)?

The skin on the face, neck, décolletage, and hands is thinner and more delicate than the rest of the skin on the body. These areas of thin, delicate skin are the most likely to wrinkle, sag, lose elasticity, and show visible signs of premature aging.

Additionally, the delicate skin on the face, neck, décolletage, and hands are most exposed to (environmental) stressors like the sun, UV rays, dry air, cold and windy weather, air pollution, and other external sources that damage the skin’s health, vitality, and appearance.

In order to combat environmental damages and premature aging of the facial skin, OS-01 FACE delivers an optimized concentration of the OS-01 peptide which has been shown to reduce the skin’s biological age, support powerful cellular repair, and boost barrier function.

OS-01 FACE specifically benefits the more delicate skin of the face, neck, and hands by:

  • Supporting barrier function
  • Improving elasticity and firmness
  • Reducing the appearance of fine lines & wrinkles
  • Increasing skin silkiness and smoothness
  • Increasing skin hydration

We recommend applying OS-01 FACE to the most delicate and/or damaged/exposed areas of your skin, like the face, hands, and neck.

For all other areas, we recommend using OS-01 BODY.

How is OS-01 BODY formulated specifically for the skin on the body, except the face?

The skin on the body is typically thicker than the delicate skin on the face. Additionally, the skin on the body tends to be drier than facial skin because the skin on the body has fewer oil-producing sebaceous glands.

OS-01 BODY specifically benefits the skin on the body by:

  • Increasing epidermal thickness
  • Improving hydration
  • Reducing flakes, irritation, and redness
  • Supporting barrier function

OS-01 BODY is also formulated with time-tested, scientifically researched ingredients like ​​Centella Asiatica extract, Sulforaphane, and ceramides which effectively heal, hydrate, and improve the thicker skin on the body.

We recommend applying OS-01 Topical Supplement BODY to your entire body. Or, apply OS-01 Topical Supplement BODY to the areas of your body where you would like to see benefits.

Can I use this OS-01 BODY on my face?

No, we do not recommend using OS-01 BODY on your face. We specifically designed the OS-01 BODY formula for optimal absorption of the OS-01 peptide and included active ingredients and supporting oils better suited for the skin on your body.

Does OS-01 FACE and OS-01 BODY have different concentrations of the OS-01 peptide?

OS-01 BODY contains a lower concentration of the peptide compared to OS-01 FACE. We measured the optimal penetration of the peptide for the average epidermal thickness of skin on the body that would work to counteract the levels of environmental stressors (UV, pollution, etc.) that are generally lower, on a daily basis, when compared to the skin of the face.

What size is the OS-01 FACE bottle?

50 mL

What size is the OS-01 BODY bottle?

250 mL

How long will my Topical Supplement last?

We estimate the 50 ml bottle of OS-01 FACE will last approximately 1-3 months when used as directed. The 250 ml bottle of OS-01 BODY will last approximately 1-2 months, when used as directed.

Are your Topical Supplements safe / clean?

We’ve applied vigorous scientific rigor and exacting standards into formulating the safest, most effective Topical Supplements possible.

Our Topical Supplements are clean, vegan and cruelty free.

The Environmental Working Group (EWG) rates skincare ingredients on a scale of 1-10, with a score of 1 being the safest and healthiest. OS-01 BODY received an average score of 1.12 and a weighted average of 1.03 on the EWG’s SkinDeep Cosmetics Database. OS-01 FACE received an average score of 1.02 and a weighted average of 1.04 on the EWG’s SkinDeep Cosmetics .

OS-O1 FACE and OS-01 BODY were also tested for human sensitization (RIPT - a clinical study to assess skin irritation) and various other toxicity tests. No adverse effects were found.

How does OS-01 FACE compare to retinol?

OS-01 FACE is safer and more effective than retinol.

Retinol targets the symptoms of aging by stimulating cell renewal which leads to peeling off the upper epidermal layers. However, retinol is often too harsh for many skin types, especially sensitive and drier skin. Negative side effects of retinol can include redness, irritation, dryness, flaking, and damage to the skin barrier which can increase skin sensitivity. When misused or overused, retinol can even compromise skin health in the long term. Skin peeling and a less resilient, weaker skin barrier are potential outcomes of such misuse.

OS-O1 FACE is a safer, highly efficacious topical supplement that extends skin health for the long-term. The proprietary peptide in OS-01 FACE targets the root cause of skin aging at the molecular level by preventing the accumulation of damaged cells and increasing cellular repair capabilities. OS-01 FACE is more gentle than retinol - and our data supports similar or better effects in improving collagen and hyaluronic acid production, along with increasing epidermal thickness.

How should retinol be used with OS-01 FACE?

Though we recommend forgoing retinol completely, OneSkin’s  OS-01 Topical Supplements can be used together with a retinol, if retinol is tolerated. You can do this by alternating your use of both products, applying the OS-01 Topical Supplements to skin during times when you’re not applying retinol, or by combining your retinol use directly with the OS-01 Topical Supplements. Both methods will allow the OS-01 peptide to help counteract the harsh effects of retinol. However, it should be noted that in order for your skin to achieve maximum absorption of the OS-01 peptide, you should apply your OS-01 Topical Supplement as the first product in your routine directly after cleansing. 

Luckily, for those with retinol sensitive skin, the OS-01 Topical Supplements are an excellent alternative to retinol - one that is better for preserving your barrier function and long-term skin health!

What are the shelf lifes of your Topical Supplements? How should they be stored?

OS-01 FACE has a shelf life of 24 months.

OS-01 BODY has a shelf life of 24 months.

Both Topical Supplements can be stored at room temperature away from direct sunlight.

What is OneSkin doing for sustainable packaging?

Packaging: Our box is 100% recyclable

OS-01 FACE: We are working to develop a bottle for OS-01 FACE that will be made from partially recycled material. Currently, once you have finished using our product, you can email support@oneskin.co to request a free shipping label to return the empty bottle to us. The empty bottle can be returned in the original box or any other packaging of your choice.

Additionally, we are developing a refillable packaging option for OS-01 FACE.

OS-01 BODY: The OS-01 BODY bottle is 100% recyclable.

All future product packaging will be chosen with sustainability in mind.

Lastly, we have partnered with Zero Carbon to offset our carbon footprint to zero! Stay tuned for more updates on our sustainability goals!

Product Usage

How should I integrate the OS-01 Topical Supplements into my current skincare routine?

At their core, our Topical Supplements are moisturizers, so we recommend applying them after cleansing and before sunscreen.

OS-01 FACE and OS-01 BODY have not been shown to produce adverse reactions with other products and ingredients, including retinol, vitamin C, and hyaluronic acid. This means that you can safely incorporate them into your current routine without any additional changes.

Remember, it’s always best to patch test any new skincare product.

Are your Topical Supplements safe to use while pregnant/breastfeeding?

We have rigorously tested our Topical Supplements for their safety on various skin types, however, we have not tested our Topical Supplements with pregnant or breastfeeding mothers.

We recommend pregnant and breastfeeding mothers show the ingredients lists to a doctor or healthcare provider to confirm safety before use. As always, it’s best to consult with a medical professional before making lifestyle changes.

Can my child use your products?

While our products are safe to use, we recommend them for all adults over the age of 18.

Science Behind OneSkin's Products

What is skinspan?

Skinspan refers to the length of time that your skin is healthy. For many, healthy skin presents as supple, smooth, and strong. Our mission is to extend your skinspan by optimizing skin health on a molecular level, increasing skin resilience and strength.

Unlike other skincare products that offer short term solutions (and might even cause long-term damage), our Topical Supplements are powered by a proprietary peptide, OS-01, which targets the root causes of aging, including cellular damage and the accumulation of aged cells, for long term, visible results.

How are your products different from regular moisturizers?

Our Topical Supplements contain a proprietary peptide, OS-01, that will not only nourish your skin, but will also proactively extend your skin health on a molecular and external level.

Why is the OS-01 peptide delivered topically?

Topical delivery ensures maximal penetration by the OS-01 peptide and efficacy to a specific area of skin. Through targeted topical application, our Topical Supplements are best able to deliver visible, noticeable improvements to the skin.

It’s also important to note that the science on the efficacy of ingestible skincare supplements is still out. Ingestible skincare supplements often degrade in stomach acid and fail to deliver any quantifiable, noticeable benefits to the skin. Combined with a healthy and balanced diet, Topical Supplements are your most effective tool to achieve faster, more visible improvements to the skin.

What current research are you working on?

Due to competitive reasons, we cannot share the research we are currently working on. When we finish our research, we will announce any findings and concluded studies in our marketing emails/newsletters and/or blog.

Is there any human data available on your Topical Supplements? Has it been published?

While we haven’t published any of our clinical data in a scientific journal yet, we have completed a 12-week clinical study with 22 patients where we collected significantly positive data showing that OS-01 FACE can improve the skin barrier, texture, hydration, and reduce fine lines and wrinkles. You can read more about our 12-week clinical study to evaluate OS-01 FACE here.

We also have an ongoing clinical study which is examining our product's ability to reduce the skin’s biological age over 6 months. We can’t wait to share the results!

I’ve read everything on your website, where can I go for more information?

You can read further into our MolClock abstract here and you can also sign up for our newsletter to receive brand updates, new research, and ongoing initiatives. If you’re interested in learning more about all things longevity and skin, you can also check out our blog (the Reference Lab) here.


What are the ingredients in your Topical Supplements?

OS-01 FACE: Water (aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide

OS-01 BODY: Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Olivate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

Are your products fragrance free?

Yes, all of OneSkin’s products are fragrance free. Due to natural ingredients, you may pick up on their own scent, but there is no added fragrance to our product.

Where are your products manufactured?

Our Topical Supplements are manufactured in California.

Where do you source your ingredients from?

We only use the highest quality ingredients available, which are sourced globally.



Do you offer international shipping?

We are able to ship to all addresses in Canada. We are not yet able to ship to any other countries outside the US and Canada.

With shipments outside of the United States, we ship DDP (Delivered Duties Paid). Shipping duties and taxes are all included in the final price.

If you have any additional questions please reach out to our support team at support@oneskin.co

How long does shipping take?

As we are currently experiencing slight shipping delays, we estimate shipping will take about 7-14 days, depending on your location and courier. Sometimes packages may arrive sooner than anticipated. Couriers depend on the location and expected timing of the shipment. Please refer to your tracking number to determine which courier will be used.

Do you offer expedited shipping?

Yes, we offer expedited shipping, but all orders placed after 12 noon PST will not process until the following business day. Orders placed on Thursday after 12 noon PST or Friday will not process until the following Monday.

How long do I have to update my shipping information after an order is placed?

Once an order is placed, it will be processed within 30 minutes, making changes to the shipping address no longer possible. Because of this, we cannot update a shipping address after it has been placed. Please double-check all shipping information before placing an order.

My package says it has been delivered, but I don’t have it.

We encourage you to reach out to your courier and create a ticket with them using your tracking number. After you do this, please reach out to our support team at support@oneskin.co for further assistance.

What happens if my package is returned to the sender due to a delivery error (wrong address, delivery complications, no access to location, etc.)?

For any “Return to Sender” packages or delivery issues with USPS, we will issue you a refund when your package is received in our warehouse. Unfortunately, we’re unable to reship packages once they leave our facility. Your tracking information will show you detailed information marked by your courier, and you may reach out to them for further information and try to intercept your package and/or schedule a pick up at your local post office.

Where can I view my tracking information?

After you place an order, you will get an email from us confirming your order and the tracking information will be included in that email. You will also be able to view your tracking information through your OneSkin account.

My items broke during delivery, can I get a new one?

We apologize for any issues that arise during the shipping process. Please reach out to our support team at support@oneskin.co with your product and pictures of the damage that occurred during shipping. They will be able to help assess the situation and either issue a refund or send a new shipment to you.

My order status says unfulfilled, what does that mean?

An unfulfilled status means your order has not yet been processed and packaged. You willl be notified via email with tracking information as soon as a label is created in our system.

Refunds, Returns, and Cancellations

What is your refund policy?

We are confident you will be more than satisfied with our products. So much so that we offer a 30-day money back guarantee on your first order. This means that you can request a refund at any point within 30 days of your first purchase and get your money back with no questions asked. That's how much we believe in our products! Please note, based on feedback, most customers state visible results occur around the 6 week mark of continued use.

Do you offer price adjustments?

While we do not offer price adjustment, we will periodically offer special promotions/discounts throughout the year. These will be announced via email when they are active. To receive promotions and other content from OneSkin, sign up for our email list at the bottom of our website home page.

How do I cancel an order?

Before you place your order, you can view the contents and the total amount in your shopping cart. Once your order has been placed, it is immediately sent to our fulfillment center to begin processing for order delivery. Because of this, we are unable to make any cancellations or changes to submitted orders, regardless of its current status.

I forgot to cancel my subscription, can I return the current shipment for a refund?

Yes, please contact us at support@oneskin.co and we will generate a return label that you can print out and use to send your shipment back. Upon receiving your order, we will issue your refund.


Can I switch my subscription between OS-01 BODY and OS-01 FACE?

No, subscription plans are separate for OS-01 FACE and OS-01 BODY. You can adjust your subscriptions via your OneSkin account or by contacting support@oneskin.co.

Can I make changes to my order once it's placed?

Once an order is placed, a label is created shortly after. We do not have the ability to adjust or make changes to your order at this time. In the case an incorrect address is entered during the checkout process, we cannot guarantee that changes can be made. However, in the event that the package is sent back to us, we can offer a refund on the items.

Do you offer OS-01 for wholesale distribution?

We are not currently offering our products for wholesale distribution. If you have any further questions about wholesale distribution you can reach out to our support team at support@oneskin.co.

Do you have a referral program?

Yes, we do! You can give $20 to a friend/family member that is good for a single bottle purchase only, and when they use your code, you will automatically receive $20 off your next purchase.

How can I apply a discount code to an existing subscription plan?

1.) Visit to oneskin.co

2.) Click "Account" in the top right corner

3.) Click "Manage your subscriptions"

4.) Click "Edit"

5.) Scroll down and click "Apply Discount"


Account Information

How do I create an account?

(Important Note: You must create an account to manage your subscription.)

You can update your payment information right through your account on our website. You can also reach out to our support team at (415) 851-6677 and update it over the phone.

  1. Click "Account" on top right of oneskin.co homepage

  2. Click "Sign Up Here" in top right

  3. Create account using the same email associated with your subscription

How do I update my payment information?

You can update your payment information directly through your account on our website. You can also reach out to our support team at (415) 851-6677 and update it over the phone.

How do I reset my account password?

You can reset your password through your account settings. If you cannot access your account to reset your password, you can enter your password on our login page and select ‘Forgot Password’ which will send you an email to update your password.

How do I update my email address?

You can update your email address directly through your account on our website. You can also reach out to our support team at support@oneskin.co or by phone at (415) 851-6677.

Contact us

What is your customer support phone number?

(415) 851-6677

If we are unable to answer your call, please leave a voicemail with your name and question and we will get back to you within 24-48 hours.

You can now text our support team directly at this same number, (415) 851-6677.

Please note, our customer service is available Monday - Friday. Inquires will be responded to in the order they are received.

Our hours are 9am until 5pm Pacific Time.

What is your customer support email address?

You can reach out to our support team at support@oneskin.co.

Please note, our customer service is available Monday - Friday. Inquires will be responded to in the order they are received.

Our hours are 9am until 5pm Pacific Time.

I’m an agency, brand, influencer, etc. who can I reach out to for a collaboration?

Please reach out to our PR team at support@oneskin.co.

How do I unsubscribe from your emails?

We are sad to see you go! To unsubscribe or manage your email preferences, open one of our emails, scroll down to the bottom of the email, and click “Unsubscribe”.