Product Overview

What is OS-01 and what does it do?

OS-01 is OneSkin’s proprietary peptide, which sits at the heart of OneSkin’s product formulations and powers OneSkin’s Topical Supplements.

The OS-01 peptide was discovered from years of research by the OneSkin team and works by improving internal markers of skin health and external markers of skin strength, effectively extending your skinspan (the length of time that your skin is healthy and strong).

Using our cutting-edge R&D process & molecular clock, the scientists at OneSkin have shown that the OS-01 peptide reduces skin's biological age and improves skin function.

Additionally, the OS-01 peptide has been shown to:

  • Increase epidermal thickness and improve cellular structure, for optimal barrier function
  • Support collagen and elastin production, for stronger, firmer skin
  • Support hyaluronic acid production, to boost hydration 
  • Repair UV damage and reduce the amount of aged cells in skin, so skin stays healthier for longer
  • Reduce hyperpigmentation in skin, otherwise known as “sun spots” and “age spots”

What is a Topical Supplement?

Just like you take vitamins and oral supplements everyday for your general health and immunity, a topical supplement is a formulation designed to improve the health and appearance of the skin.

Topical supplements are applied to specific areas of the skin to deliver targeted, visible results. Our topical supplements deliver OS-01, a proprietary peptide that extends your skin health, or your skinspan.

What is the difference between OS-01 FACE and OS-01 BODY?

OS-01 BODY is specially formulated for use on your body’s skin and OS-01 FACE is specifically formulated for use on your face. Read the next two questions for more details..

How is OS-01 FACE formulated for use on areas exposed to the most damage (face, hands, and neck)?

The skin on the face, neck, décolletage, and hands is thinner and more delicate than the rest of the skin on the body. These areas of thin, delicate skin are the most likely to wrinkle, sag, lose elasticity, and show visible signs of premature aging.

Additionally, the delicate skin on the face, neck, décolletage, and hands are most exposed to (environmental) stressors like the sun, UV rays, dry air, cold and windy weather, air pollution, and other external sources that damage the skin’s health, vitality, and appearance.

In order to combat environmental damages and premature aging of the facial skin, OS-01 FACE delivers an optimized concentration of the OS-01 peptide which has been shown to reduce the skin’s biological age, support powerful cellular repair, and boost barrier function.

OS-01 FACE specifically benefits the more delicate skin of the face, neck, and hands by:

  • Supporting barrier function
  • Improving elasticity and firmness
  • Reducing the appearance of fine lines & wrinkles
  • Increasing skin silkiness and smoothness
  • Increasing skin hydration

We recommend applying OS-01 FACE to the most delicate and/or damaged/exposed areas of your skin, like the face, hands, and neck.

For all other areas, we recommend using OS-01 BODY.

How is OS-01 BODY formulated specifically for the skin on the body, except the face?

The skin on the body is typically thicker than the delicate skin on the face. Additionally, the skin on the body tends to be drier than facial skin because the skin on the body has fewer oil-producing sebaceous glands.

OS-01 BODY specifically benefits the skin on the body by:

  • Increasing epidermal thickness
  • Improving hydration
  • Reducing flakes, irritation, and redness
  • Supporting barrier function

OS-01 BODY is also formulated with time-tested, scientifically researched ingredients like ​​Centella Asiatica extract, Sulforaphane, and ceramides which effectively heal, hydrate, and improve the thicker skin on the body.

We recommend applying OS-01 Topical Supplement BODY to your entire body. Or, apply OS-01 Topical Supplement BODY to the areas of your body where you would like to see benefits.

Can I use this OS-01 BODY on my face?

No, we do not recommend using OS-01 BODY on your face. We specifically designed the OS-01 BODY formula for optimal absorption of the OS-01 peptide and included active ingredients and supporting oils better suited for the skin on your body.

Do OS-01 FACE and OS-01 BODY have different concentrations of the OS-01 peptide?

OS-01 BODY contains a lower concentration of the peptide compared to OS-01 FACE. We measured the optimal penetration of the peptide for the average epidermal thickness of skin on the body that would work to counteract the levels of environmental stressors (UV, pollution, etc.) that are generally lower, on a daily basis, when compared to the skin of the face.

How does PREP specifically prepare my skin for the OS-01 FACE Topical Supplement?

Dead skin cells, dirt, and ingredients in makeup and sunscreen can create build-up on the skin that prevents products from fully absorbing. PREP gently dissolves this build-up without disrupting your natural lipid barrier so that OS-01 FACE can absorb more readily–ensuring you see maximum results from our OS-01 peptide.

What size is the OS-01 FACE bottle?

50 mL

What size is the OS-01 BODY bottle?

250 mL

What size is the PREP bottle?

200 mL

How long will my Topical Supplement last?

We estimate the 50 ml bottle of OS-01 FACE will last approximately 1-3 months when used as directed. The 250 ml bottle of OS-01 BODY will last approximately 1-2 months, when used as directed.

How long will one bottle of PREP last?

We estimate that the 200 ml bottle of PREP will last approximately 1-2 months, when used as directed.

Are your Products safe / clean?

We’ve applied vigorous scientific rigor and exacting standards into formulating the safest, most effective products possible.

Our products are clean, vegan and cruelty free.

The Environmental Working Group (EWG) rates skincare ingredients on a scale of 1-10, with a score of 1 being the safest and healthiest. OS-01 BODY received an average score of 1.93 and a weighted average of 1.03 based on the EWG’s SkinDeep Cosmetics Database scoring guidelines. OS-01 FACE received an average score of 1.02 and a weighted average of 1.04 based on the EWG’s SkinDeep Cosmetics scoring guidelines. PREP received an average score of 1.235 and a weighted average of 1.095 based on the EWG’s SkinDeep Cosmetics Database scoring guidelines.

OS-O1 FACE, OS-01 BODY, and PREP were also tested for human sensitization (RIPT - a clinical study to assess skin irritation) and various other toxicity tests. No adverse effects were found.

How does OS-01 FACE compare to retinol?

Overall, our research shows that while retinol is commonly considered the gold standard anti-aging ingredient, it also has significant downsides, like potentially compromised barrier function and accelerated irritation, that may ultimately degrade long-term skin health. Alternatively, OneSkin’s OS-01 Topical Supplements, powered by our OS-01 peptide, offer comparable benefits, including an increase in collagen production and epidermal thickness, without the drawbacks. To learn more about retinol’s impact on skin and how OS-01 compares, click here.

How should retinol be used with OS-01 FACE?

If your skin tolerates retinol, you can continue using it with OS-01 FACE. In fact, OS-01 FACE helps counteract retinol’s harsher side effects, including dryness, peeling, sensitivity, itching, and redness. This is thanks to our OS-01 peptide’s ability to: 

  • Increase production of hyaluronic acid, collagen, and elastin 
  • Improve skin hydration and barrier function 
  • Increase epidermal thickness 
  • Repair cellular damage and soothe irritated skin

You can incorporate OS-01 FACE with retinol in one of two ways:

  1. Alternate OS-01 FACE and retinol: Alternating allows your skin to reap the benefits of both products without either of them interfering with the absorption of the other. Since retinol should only be applied at night, you can alternate the two by using OS-01 FACE in the mornings. 
  2. Combine OS-01 FACE and retinol: When combining retinol with OS-01 FACE in the same skin care routine, it’s up to you to decide which product to apply first. Just keep in mind that the OS-01 peptide will achieve maximum penetration if it’s applied as the first step after cleansing. 

No matter which method you use, the OS-01 peptide will still help to counteract retinol’s harsh side effects. If your skin is sensitive to retinol, skip it and just use OS-01 FACE instead. It delivers many of the same benefits without any of the drawbacks.

What are the shelf lives of your products? How should they be stored?

OS-01 FACE has a shelf life of 24 months.

OS-01 BODY has a shelf life of 24 months.

PREP has a shelf life of 24 months.

All OneSkin products can be stored at room temperature away from direct sunlight.

What is OneSkin doing for sustainable packaging?

Packaging: Our box is 100% recyclable

OS-01 FACE now uses refillable packaging.

The OS-01 BODY bottle and PREP bottle are 100% recyclable.

All future product packaging will be chosen with sustainability in mind.

Lastly, we have partnered with Zero Carbon to offset our carbon footprint to zero! Stay tuned for more updates on our sustainability goals!

Product Usage

How should I integrate the OS-01 Topical Supplements into my current skincare routine?

At their core, our Topical Supplements are moisturizers, so we recommend applying them after cleansing and before sunscreen.

OS-01 FACE and OS-01 BODY have not been shown to produce adverse reactions with other products and ingredients, including retinol, vitamin C, and hyaluronic acid. This means that you can safely incorporate them into your current routine without any additional changes. To learn more about how to integrate OneSkin into your current routine, click here.

Remember, it’s always best to patch test any new skincare product.

How should I integrate PREP into my current skincare routine?

Use PREP every evening to cleanse your skin, followed immediately by OS-01 FACE. If you have oily skin and prefer to cleanse both morning and night, you can also use PREP to wash your face at the start of each day. 

PREP has not been shown to produce adverse reactions when used with other products and can be safely incorporated into your current routine.

Remember, it’s always best to patch test any new skincare product.

Are your products safe to use while pregnant/breastfeeding?

We have rigorously tested our products for their safety on various skin types, however, we have not tested our products with pregnant or breastfeeding mothers.

We recommend pregnant and breastfeeding mothers show the ingredients lists to a doctor or healthcare provider to confirm safety before use. As always, it’s best to consult with a medical professional before making lifestyle changes.

Can my child use your products?

While our products are safe to use, we recommend them for all adults over the age of 18.

Science Behind OneSkin's Products

What is skinspan?

Skinspan refers to the length of time that your skin is healthy. For many, healthy skin presents as supple, smooth, and strong. Our mission is to extend your skinspan by optimizing skin health on a molecular level, increasing skin resilience and strength.

Unlike other skincare products that offer short term solutions (and might even cause long-term damage), our Topical Supplements are powered by a proprietary peptide, OS-01, which targets the root causes of aging, including cellular damage and the accumulation of aged cells, for long term, visible results.

How are your Topical Supplements different from regular moisturizers?

Our Topical Supplements contain a proprietary peptide, OS-01, that will not only nourish your skin, but will also proactively extend your skin health on a molecular and external level.

Why is the OS-01 peptide delivered topically?

Topical delivery ensures maximal penetration by the OS-01 peptide and efficacy to a specific area of skin. Through targeted topical application, our Topical Supplements are best able to deliver visible, noticeable improvements to the skin.

It’s also important to note that the science on the efficacy of ingestible skincare supplements is still out. Ingestible skincare supplements often degrade in stomach acid and fail to deliver any quantifiable, noticeable benefits to the skin. Combined with a healthy and balanced diet, Topical Supplements are your most effective tool to achieve faster, more visible improvements to the skin.

What current research are you working on?

Due to competitive reasons, we cannot share the research we are currently working on. When we finish our research, we will announce any findings and concluded studies in our marketing emails/newsletters and/or blog.

Is there any human data available on your Topical Supplements? Has it been published?

While we haven’t published any of our clinical data in a scientific journal yet, we have completed a 12-week clinical study with 22 patients where we collected significantly positive data showing that OS-01 FACE can improve the skin barrier, texture, hydration, and reduce fine lines and wrinkles. You can read more about our 12-week clinical study to evaluate OS-01 FACE here.

We also have an ongoing clinical study which is examining our product's ability to reduce the skin’s biological age over 6 months. We can’t wait to share the results!

I’ve read everything on your website, where can I go for more information?

You can read further into our MolClock abstract here and you can also sign up for our newsletter to receive brand updates, new research, and ongoing initiatives. If you’re interested in learning more about all things longevity and skin, you can also check out our blog (the Reference Lab) here.


What are the ingredients in your products?

OS-01 FACE Topical Supplement: Water (aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapeptide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocopheryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol, Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide

OS-01 BODY Topical Supplement: Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Olivate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

PREP: Water, Sodium Laurylglucosides Hydroxypropylsulfonate, Cocamidopropyl Hydroxysultaine, Disodium Lauryl Sulfosuccinate, Glycerin, Sodium Hydroxypropylphosphate Laurylglucoside Crosspolymer, Sodium Grapeseed Amidopropyl PG-Dimonium Chloride Phosphate, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Breu Branco Resin, Caprylyl Glycol, Phenoxyethanol, Lonicera Japonica (Honeysuckle) Flower Extract, Niacinamide, Sorbic Acid, Arnica Montana (Arnica Flower) Extract, Tetrasodium Glutamate Diacetate.


Are your products fragrance free?

Yes, all of OneSkin’s products are fragrance free. Due to natural ingredients, you may pick up on their own scent, but there is no added fragrance to our product.

Where are your products manufactured?

Our products are manufactured in California.

Where do you source your ingredients from?

We only use the highest quality ingredients available, which are sourced globally.

Refillable Packaging

Can I use my non-reusable OS-01 FACE bottle with the refillable package?

No, the OS-01 FACE bottle you have is not compatible with the refillable pouches. The new bottles will look very similar, but the pouch will be removable from the shell, so you can easily replace the inner pouch any time needed.

How can I change my subscription to the refillable pouches?

There’s nothing you need to do to make the change! All subscriptions will be automatically switched over to refillable pouches. Your next subscription order will include the refillable bottle with the first pouch already inside and an instructional insert to guide you through how to use the new packaging properly.

How much will I be saving with the refillable pouches?

One time purchase of the refillable OS-01 FACE starter kit (bottle & pouch) will remain the same at $120. However, if you already have the new refill bottle, and are not a subscriber, you’re able to place an order for only the pouch, at a rate of $117. Subscription rates will remain the same at $99.

When can I expect to receive the refillable pouches of OS-01 FACE and/or PREP?

If you’re on a subscription plan, you can expect your next order to come with the refillable bottle that allows you to remove the pouch. Every order you receive after will be just the pouch.

Will the OS-01 BODY bottles be refillable too?

Not yet! However, our BODY bottles are recyclable. Changing over to refillable pouches for OS-01 FACE was a year in the making. Now that we’ve made the change, our focus is on developing new products like PREP and EYE that will also launch with refillable packaging. Once we’ve completed those launches, we’ll redirect our focus to making OS-01 BODY refillable as well.

Why can’t I find the refillable pouches on the website?

Our website will be updated within the next 2-3 weeks to reflect refillable pouch options for purchase of OS-01 FACE.

How can I clean my reusable pump?

We recommend cleaning the pump every few months or whenever you start to notice product build up to avoid any potential carry-over. In between refills, simply place the bottom of the pump in a shallow container filled with rubbing alcohol, then pump through 10x and air dry.

How can I request a new pump, bottle, or plastic shell?

If you are in need of a new pump or plastic shell, please email support@oneskin.co and we will arrange to ship you a replacement.



If your order is placed before 11am Pacific Time it will ship the same business day. If your order is placed after 11amm Pacific Time, it will not get shipped until the following business day. Orders placed on Friday after 12pm PT will not ship until the following business day, Monday. Orders can take up to 7 business days to arrive. Depending on your location, orders can arrive sooner than 7 business days. All standard shipping orders will be delivered by USPS.


Do you offer international shipping?

We are able to ship to all addresses in Canada. We are not yet able to ship to any other countries outside the US and Canada.

With shipments outside of the United States, we ship DDP (Delivered Duties Paid). Shipping duties and taxes are all included in the final price.

If you have any additional questions please reach out to our support team at support@oneskin.co

How long does shipping take?

As we are currently experiencing slight shipping delays, we estimate shipping will take about 7-14 days, depending on your location and courier. Sometimes packages may arrive sooner than anticipated. Couriers depend on the location and expected timing of the shipment. Please refer to your tracking number to determine which courier will be used.

Do you offer expedited shipping?

Yes, we offer expedited shipping, but all orders placed after 11 AM PST will not process until the following business day. Orders placed on Thursday after 11 AM PST or Friday will not process until the following business day, Monday.

How long do I have to update my shipping information after an order is placed?

Once an order is placed, it will be processed within 30 minutes, making changes to the shipping address no longer possible. Because of this, we cannot update a shipping address after it has been placed. Please double-check all shipping information before placing an order.

My package says it has been delivered, but I don’t have it.

We encourage you to reach out to your courier and create a ticket with them using your tracking number. After you do this, please reach out to our support team at support@oneskin.co for further assistance.

What happens if my package is returned to the sender due to a delivery error (wrong address, delivery complications, no access to location, etc.)?

For any “Return to Sender” packages or delivery issues with USPS, we will issue you a refund when your package is received in our warehouse. Unfortunately, we’re unable to reship packages once they leave our facility. Your tracking information will show you detailed information marked by your courier, and you may reach out to them for further information and try to intercept your package and/or schedule a pick up at your local post office.

Where can I view my tracking information?

After you place an order, you will get an email from us confirming your order and the tracking information will be included in that email. You will also be able to view your tracking information through your OneSkin account.

My items broke during delivery, can I get a new one?

We apologize for any issues that arise during the shipping process. Please reach out to our support team at support@oneskin.co with your product and pictures of the damage that occurred during shipping. They will be able to help assess the situation and either issue a refund or send a new shipment to you.

My order status says unfulfilled, what does that mean?

An unfulfilled status means your order has not yet been processed and packaged. You willl be notified via email with tracking information as soon as a label is created in our system.

Refunds, Returns, and Cancellations

What is your refund policy?

We are confident you will be more than satisfied with our products. So much so that we offer a 30-day money back guarantee on your first order. This means that you can request a refund at any point within 30 days of your first purchase and get your money back with no questions asked. That's how much we believe in our products! Please note, based on feedback, most customers state visible results occur around the 6 week mark of continued use.

Do you offer price adjustments?

While we do not offer price adjustment, we will periodically offer special promotions/discounts throughout the year. These will be announced via email when they are active. To receive promotions and other content from OneSkin, sign up for our email list at the bottom of our website home page.

How do I cancel an order?

Before you place your order, you can view the contents and the total amount in your shopping cart. Once your order has been placed, it is immediately sent to our fulfillment center to begin processing for order delivery. Because of this, we are unable to make any cancellations or changes to submitted orders, regardless of its current status.

I forgot to cancel my subscription, can I return the current shipment for a refund?

Yes, please contact us at support@oneskin.co and we will generate a return label that you can print out and use to send your shipment back. Upon receiving your order, we will issue your refund.


Can I switch my subscription between OS-01 BODY and OS-01 FACE?

No, subscription plans are separate for OS-01 FACE and OS-01 BODY. You can adjust your subscriptions via your OneSkin account or by contacting support@oneskin.co.

Can I make changes to my order once it's placed?

Once an order is placed, a label is created shortly after. We do not have the ability to adjust or make changes to your order at this time. In the case an incorrect address is entered during the checkout process, we cannot guarantee that changes can be made. However, in the event that the package is sent back to us, we can offer a refund on the items.

Do you offer your products for wholesale distribution?

We are not currently offering our products for wholesale distribution. If you have any further questions about wholesale distribution you can reach out to our support team at support@oneskin.co.

Do you have a referral program?

Yes, we do! You can give $20 to a friend/family member that is good for a single bottle purchase only, and when they use your code, you will automatically receive $20 off your next purchase.

How can I apply a discount code to an existing subscription plan?

1.) Visit to oneskin.co

2.) Click "Account" in the top right corner

3.) Click "Manage your subscriptions"

4.) Click "Edit"

5.) Scroll down and click "Apply Discount"


Account Information

How do I create an account?

(Important Note: You must create an account to manage your subscription.)

You can update your payment information right through your account on our website. You can also reach out to our support team at (415) 851-6677 and update it over the phone.

  1. Click "Account" on top right of oneskin.co homepage

  2. Click "Sign Up Here" in top right

  3. Create account using the same email associated with your subscription

How do I update my payment information?

You can update your payment information directly through your account on our website. You can also reach out to our support team at (415) 851-6677 and update it over the phone.

How do I reset my account password?

You can reset your password through your account settings. If you cannot access your account to reset your password, you can enter your password on our login page and select ‘Forgot Password’ which will send you an email to update your password.

How do I update my email address?

You can update your email address directly through your account on our website. You can also reach out to our support team at support@oneskin.co or by phone at (415) 851-6677.

Contact us

How Can I Contact Your Support Team?

  • Text us at (415) 851-6677 *Please note we can only text with US based phone numbers*
  • Call us a at (415) 851-6677. Please note, our phone line is temporarily unavailable. Please use email, live chat, or texting to contact support. 
  • Email us at support@oneskin.co.
  • Chat with us through the chat icon, found in the bottom right corner of our website.

When Is Your Support Team Available?

We will be available by email from 6am - 6pm 7 days/week and for texting and phone calls from Monday-Friday from 9 AM until 3PM Pacific Standard Time - If we are unable to answer your call, please leave a message and we will return your call within 1-2 business days.

We will reply to all emails Monday through Friday within 1-2 business days.

How Can I Partner With Your Company?

For partnership inquiries, please reach out to partners@oneskin.co.

Discoveries are for those that seek them.

Get science-backed skin tips, longevity insights, exclusive brand updates, and more in your inbox.