The future of skin health is here

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The first topical supplement designed to extend your skinspan on a molecular level.

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We have a secret… We aren’t a skincare company

We are a longevity company. Our team is comprised of PhD-level aging experts. We’ve spent years in a lab creating the first topical skin supplement designed to extend your skinspan; the time your skin is healthy and youthful. And here you thought all supplements were pills.

Right for all skin types
(we all age, after all)
Data-backed claims
peptide, OS-01
Developed by longevity Scientists
Vegan and cruelty free
Safe and clean ingredients

Healthy skin is happy skin

(Just take it from our customers!)


“After only a few days I already see noticeable improvement in my otherwise dry skin. Thanks OneSkin for developing this excellent product!”

-Claudia V.

“My skin absolutely loves OS-01. I've never had any skin cream hydrate my face so well. My skin is firmer, more elastic and evenly toned. Very pleased with your product and highly recommend it to everyone. Bravo.”

-Beau W.

“This is by far the most effective product I’ve used to date. I have tried all sorts of anti-aging moisturizers and this has them all best hands down. Luxurious feel and scent!”

-Megan L.

“At 67, having ceased taking hormone replacement therapy (HRT) about three years ago, I have been dismayed at how dry and wrinkled my skin has become. Using One Skin daily for almost two months, I see a distinct improvement in the suppleness and youthfulness of my face.”

-Emily W.

“After using the OS-01 as a night cream, I noticed that my skin went from dry and dull to moisturized and firm! I'd definitely recommend it to anyone who has combination skin.”

-Justin L.

“I love that it only takes a small amount to go a long way… my skin feels more hydrated than ever before and dark spots are fading!”

-Judi A.

Scientifically and Clinically backed

OS-01 Supporting Data

We performed a 12-week clinical study to validate and quantify the impact of OS-01 in improving skin health. Our results showed that OS-01 is clinically proven to strengthen the skin barrier in addition to providing remarkable visual benefits.

12 Weeks
Base Line
  • Improved Skin Barrier (Average Improvement + 15%)*
  • Improved Skin Elasticity (Shown in 90% of users)**
  • Improved Skin Evenness,
    Radiance, Pores, & Firmness (Shown in 95.5% of users)**
  • Less Wrinkles (Shown in 87% of users)
  • Improved Skin Smoothness
    & Overall Appearance (Shown in 100% of users)

*Instrumental Evaluation - Vapometer analysis

*Double-blind expert clinical grader evaluation

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Meet OS-O1, the first ingredient to target the root causes of skin aging

Our product acts at the molecular level. Our proprietary peptide, OS-O1, is scientifically proven to

Plus, our ultra hydrating and weightless formula will leave you with healthier, stronger, and more hydrated skin without an oily residue, making it the perfect face cream for dry skin.

Healthy skin is happy skin

(Just take it from our beta testers)


As a brand whose mission is to inspire healthy aging, we don’t identify with the term “anti-aging” and here’s why:

Much of the anti-aging skincare industry has been built on empty promises with top anti-aging products lacking validated claims and exploiting age-related anxiety and fear.

At OneSkin, we recognize that the goal of the best anti-aging skincare products shouldn't be only to improve appearances, which often forces consumers to compromise on long-term skin health, but rather to treat the underlying source of skin aging, a consequence of which will be improved appearances.

We are developing best-in-class solutions to aging with a new mindset - one that’s not anti-aging, but pro-aging in the healthiest and most beautiful way possible. We believe the best anti-aging treatment is one that is rooted in science, with data-backed claims. That’s why our Topical Supplement goes beyond placing a metaphorical band-aid on aging skin — it addresses the molecular changes associated with aging to not only boost skin health, but overall health as well.

Skin health is a marathon, not a sprint

In the same way you take daily vitamins to keep yourself healthy, daily application of our science-backed topical supplement promotes long-lasting effects to keep your skin healthy, hydrated, and strong.

Unlike other top-rated anti-aging treatments, which promise quick fixes, can dry skin out, and may even damage skin in the long run, OneSkin promotes long-term skin health and hydration at the molecular level. Our topical supplement works over time, penetrating the deepest layer of the skin to stimulate change, making OneSkin the best face cream for dry skin. Most users start seeing healthier, stronger, and better looking skin in 4-8 weeks with daily use.

Learn about our Topical Supplement